Pit Bull Neurological Disorders

Pit bulls affected with cerebellar cortical disintegration don't show symptoms until they're already adults.
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Pit bulls, or American Staffordshire terriers, can suffer from a genetic neurological disorder called cerebellar cortical disintegration. Because this disease shows up in adulthood, it's not uncommon for affected dogs to be bred, passing it on to another generation. Have your pit bull genetically tested before making breeding decisions.

Cerebellar Cortical Disintegration

Cerebellar cortical disintegration, also known as cerebellar cortical abiotrophy or ataxia, affects a dog's ability to balance. Approximately 1 in 400 pit-bull-type dogs might suffer from this disorder. This disease results in premature aging and death of cells in the cerebellum, the part of the brain in charge of coordination. While cerebellar cortical disintegration often affects other dog breeds in puppyhood, that's not true of the pit bull or American Staffordshire terrier.


Symptoms of cerebellar cortical disintegration don't appear until an affected pit bull is between the ages of 2 and 6, or ever later. Early signs are subtle -- the dog might appear to be just a bit "off." He might appear fine walking on flat surfaces; but if the terrain shifts or he changes direction, he might stumble or fall over. As the disintegration progresses, the pit bull can no longer negotiate stairs or perform other simple tasks. He might exhibit nystagmus, a condition in which his eyes move in various directions. Eventually, the dog loses the ability to walk.


Along with a physical examination, your vet can diagnose cerebellar ataxia via magnetic resonance imaging. There is no cure for the disease. Make your dog as comfortable as possible, keeping him on firm surfaces and helping him navigate. Eventually, you will have to consider euthanizing your dog. According to a 2004 study published in the Journal of Veterinary Internal Medicine, the time from onset of clinical signs to varied from six months to over six years, with the majority of affected dogs put down within two to four years after diagnosis.

Genetic Testing

To avoid the heartache of dealing with a dog with cerebellar ataxia, don't purchase a Staffy puppy unless he has been genetically tested and found free of the disorder. A genetics laboratory requires either a blood sample or cheek swab in order to conduct the DNA testing. The results will show whether your dog is normal and will not develop or transmit the disease; or is a carrier, who won't develop the disease himself but will transmit it to 50 percent of his offspring; or is affected. If it's the latter, not only will he develop the disease, but all his offspring will have it.

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